|
KMID : 0377519830080040315
|
|
Chung-Ang Journal of Medicine
1983 Volume.8 No. 4 p.315 ~ p.323
|
|
|
Chronological Changes of Na^+-K^+ ATPase Activity and the Thiopental Effects on it in the Complete Ischemic Rat Brain
|
|
Kim Joo-Myung
Rhim Kwang-Seh
|
|
|
Abstract
|
|
|
|
Since Schwartz et at. (1976) reported that in the ischemic state, Na^+-K^+ ATPase activity of the brain was reduced, numerous authorities have agreed with him, but chronological sequence of the subcellular metabolic mechanisms of the phenomenon is still obscure. Rehncrona et al. (1981), Demopoulos et al. (1977) and Hass et al. (1981) proposed different mechanisms about it but none of them are accepted with an accord. To make us more chaotic, MacMillan (1982) criticized the previous reports and insisted that Na^+-K^+ ATPase showed a capability for enhanced activity in the complete ischemic rat brain. This study documented Na+-K^+ ATPase activity as well as the thiopental sodium effect on it chronologically in the rat brain induced to complete ischemia produced by decapitation. We obtained the results that Na^+-K^+ ATPase activity reduced significantly from 10 minutes after decapitation and gradually reduced with the passage of the time. Na^+-K^+ ATPase activity reduction at 30 minutes after decapitation approaches to 50% of the control. On the contrary, the thiopental(50mg/kg) group showed no significant reduction of Na^+-K^+ ATPase activity until 30 minutes after decapitation. There results suggested us that ischemic insult produced cell membrane disintegration and the thiopental was protective to such a destructive sequence of cell membrane.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|